Both chips operate on DDR5 memory, but they diverge sharply on capacity ceiling and data integrity support. The Ryzen 9 Pro 9945 supports up to 192 GB of RAM — three times the M5's 64 GB maximum. For memory-intensive professional workloads like large dataset analysis, virtual machines, or high-resolution video editing with many simultaneous streams, that headroom is not merely a spec sheet luxury; it can be the difference between a workflow running smoothly and hitting a hard wall.
The M5 counters with faster peak memory throughput at 6400 MHz versus the Ryzen's 5600 MHz. Higher memory speed reduces latency and increases bandwidth, which benefits the M5's unified memory architecture particularly well — its CPU and GPU share the same pool, so faster RAM has a multiplying effect across both compute and graphics tasks. That said, the real-world perceptible gap between these two speeds in everyday use is modest.
The most professionally significant differentiator, however, may be ECC memory support on the Ryzen 9 Pro 9945. ECC (Error-Correcting Code) memory detects and corrects single-bit memory errors on the fly — a critical feature for workstations handling financial data, scientific computation, or any environment where silent data corruption is unacceptable. The M5 lacks this entirely. Overall, the Ryzen 9 Pro 9945 holds a clear advantage for enterprise and professional workstation use cases, while the M5's speed edge is a narrower, more situational benefit.