Both the Asus B850M AYW Gaming Wi-Fi and the MSI B850M Gaming Plus Wi-Fi6E share a very solid common foundation: they use the same AM5 socket and B850 chipset, come in a Micro-ATX form factor, support overclocking, feature RGB lighting, dual BIOS, Bluetooth 5.3, and HDMI 2.1. Both also carry a 3-year warranty. For a buyer who cares only about these core traits, either board is a peer-level choice.
The meaningful differences surface in two areas. First, wireless connectivity: the MSI extends its Wi-Fi support to Wi-Fi 6E (802.11ax), while the Asus tops out at Wi-Fi 6. Wi-Fi 6E opens up the 6 GHz band, which in practice means less congestion and higher throughput in environments with many competing devices — a real advantage if your router already supports 6E. Second, the MSI offers an easy BIOS reset mechanism, which the Asus lacks. This is a small but practical convenience during initial builds or overclocking sessions, where BIOS recovery is not uncommon. The physical size difference — the Asus measures 221 × 244 mm versus the MSI's 243.8 × 243.8 mm — is minor and unlikely to affect case compatibility for standard Micro-ATX builds.
Based strictly on the provided specs, the MSI B850M Gaming Plus Wi-Fi6E has a clear edge in this group. Its Wi-Fi 6E support is a forward-looking advantage for users with compatible networking hardware, and the easy BIOS reset adds a tangible usability benefit at no apparent cost elsewhere. The Asus is not deficient, but it offers no compensating differentiator in these general specs to close that gap.