At a glance, the Asus ROG Strix B850-A and the MSI Pro B840-P are nearly identical in their general profile: both use the AM5 socket with an ATX form factor, ship with Wi-Fi 7 and Bluetooth 5.4, support HDMI 2.1, feature RGB lighting, dual BIOS, and carry a 3-year warranty. Their physical footprints are also virtually the same, differing by less than 0.5 mm in each dimension. For most users scanning this category, the two boards look like a dead heat.
The single meaningful differentiator here is the chipset: the ROG Strix runs on B850, while the MSI Pro uses the lower-tier B840. Within AMD's hierarchy, B850 sits above B840 and unlocks full memory overclocking support, including EXPO profiles for high-speed DDR5 kits. B840, by contrast, is AMD's entry-level chipset in this generation and imposes tighter restrictions on memory tuning. Both boards are listed as ″easy to overclock,″ but that descriptor is more meaningful on the B850, where the platform actually supports it without limitations. If you plan to pair either board with fast DDR5 RAM, the B850 chipset on the ROG Strix will let you run those kits at their rated speeds, whereas the B840 on the MSI Pro may not.
Edge: Asus ROG Strix B850-A. Every shared feature in this group is equivalent, but the B850 chipset gives the ROG Strix a tangible, real-world advantage for anyone who wants to get full performance from modern DDR5 memory. The MSI Pro B840-P is a reasonable alternative only if memory overclocking is not a priority and the lower platform cost is the goal.