Both the Asus TUF Gaming B850-E Wi-Fi and the Asus TUF Gaming B850-Plus WiFi share the same fundamental platform: AM5 socket, B850 chipset, standard ATX form factor (244 × 305 mm), and identical HDMI 2.1 output. Both support overclocking, dual BIOS, RGB lighting, and carry a 3-year warranty — so for the vast majority of build considerations, they are on equal footing.
The meaningful differences come down to wireless connectivity and BIOS management. The B850-Plus WiFi pulls ahead on wireless, adding Wi-Fi 7 (802.11be) to its stack, whereas the B850-E tops out at Wi-Fi 6E. In practice, Wi-Fi 7 offers significantly higher theoretical throughput and lower latency — particularly relevant if you have a Wi-Fi 7 router and want to future-proof your build. The B850-Plus also edges ahead with Bluetooth 5.4 versus 5.3 on the B850-E, bringing marginally improved connection stability and energy efficiency. On the flip side, the B850-E includes an easy BIOS reset feature that the B850-Plus lacks — a small but genuinely useful convenience when troubleshooting failed overclocks or memory training issues.
Overall, the B850-Plus WiFi has a clear connectivity edge thanks to Wi-Fi 7 and the newer Bluetooth revision, making it the stronger choice for users who prioritize cutting-edge wireless performance. The B850-E counters with its easier BIOS reset, which appeals to builders who frequently tinker with settings, but that single convenience feature does not outweigh the wireless advantages of its sibling for most users.