Both headphones share a 40 mm driver size and an identical low-end floor of 20 Hz, and both feature active noise cancellation — so the baseline sound engineering is comparable. The divergence emerges at the top of the frequency range: the Edifier ES850NB extends to 40,000 Hz, while the OneOdio Focus A6 caps out at 20,000 Hz, which is the approximate upper limit of human hearing. In practice, an extended high-frequency ceiling is most relevant for hi-res audio formats; whether it yields an audible difference in everyday listening is debatable, but it signals a deliberate tuning choice aimed at audiophile-leaning users.
A more tangible real-world split is found in how each headphone handles noise isolation beyond ANC. The Focus A6 adds passive noise reduction — physical attenuation from the ear cup seal — which works even when the electronics are off and can complement ANC when it is active. The ES850NB omits this entirely, relying solely on its active system. For commuters or anyone in loud environments, the layered isolation of the Focus A6 can make a perceptible difference in quieter perceived noise floors.
Countering that, the ES850NB supports spatial audio, which the Focus A6 does not. Spatial audio processing can meaningfully expand the perceived soundstage, particularly for film, gaming, or immersive music content. On balance, the two products target subtly different listener profiles: the ES850NB edges ahead for spatial and hi-res audio enthusiasts, while the Focus A6 has a practical noise-isolation advantage for users prioritizing silence in loud environments.