Both boards share the same core platform foundation: the AM5 socket with a B840 chipset in a Micro-ATX form factor, supporting the same Ryzen 7000/8000 series CPUs. They also match on HDMI 2.1 output, easy overclocking, RGB lighting, and a 3-year warranty — so for pure CPU compatibility and build flexibility, neither holds an advantage over the other.
The most significant differentiator in this group is wireless connectivity. The MSI B840M Gaming Plus Wi-Fi 6E includes both Wi-Fi 6E and Bluetooth, while the MSI Pro B840M-B offers neither. In practical terms, this means the Gaming Plus can connect to 6 GHz band networks for lower latency and higher throughput without needing a separate adapter — a real convenience for cable-free desktops. For the Pro B840M-B, users who need wireless connectivity will have to budget for and install a PCIe or USB adapter.
There is also a subtle physical difference: the Gaming Plus measures 243.8 × 243.8 mm (a perfect square footprint), while the Pro B840M-B is slightly shorter at 226 mm tall with the same 243.8 mm width. This could matter in very compact Micro-ATX cases with tight vertical clearance. Overall, the Gaming Plus holds a clear edge in this group purely due to its built-in wireless capabilities — unless the user is building a strictly wired workstation on a tight budget, in which case the Pro B840M-B's smaller height may offer a minor fit advantage in constrained enclosures.