At a foundational level, the MSI B850 Gaming Plus WiFi and the MSI Pro B850-VC Wi-Fi are nearly identical twins. Both use the AM5 socket with a B850 chipset, adopt the standard ATX form factor (304.8 × 243.8 mm), and share the same wireless stack — Wi-Fi 7 (802.11be) with backwards compatibility down to Wi-Fi 4, plus Bluetooth 5.4. Both boards also support overclocking, offer easy BIOS reset, carry a dual BIOS for recovery safety, and come backed by a 3-year warranty. For most builders, these shared traits represent the bulk of day-to-day usability.
The one concrete difference in this spec group is RGB lighting: the Gaming Plus WiFi has it, the Pro B850-VC Wi-Fi does not. This is purely aesthetic — it has zero impact on performance, thermals, or stability. If you are building inside a windowed case and want the board to contribute to an illuminated build, the Gaming Plus WiFi is the only option here. If RGB is irrelevant or actively unwanted — common in office, workstation, or minimalist builds — the Pro B850-VC Wi-Fi's omission of it is a non-issue.
For this spec group, the two boards are effectively tied on every feature that matters technically. The Gaming Plus WiFi holds a narrow edge for aesthetics-focused builders solely due to its RGB support, while the Pro B850-VC Wi-Fi offers no disadvantage for anyone indifferent to lighting. The decision here comes down entirely to personal preference on visual style, not capability.