The Asus Prime B650-Plus Wi-Fi uses an AM5 socket paired with the B650 chipset and comes in the standard ATX form factor, measuring 305 mm wide and 244 mm tall. It supports Wi-Fi across multiple generations — 802.11n, 802.11ac, and up to Wi-Fi 6E (802.11ax) — alongside Bluetooth 5.3, though aptX is not included. The board supports HDMI 2.1 output and offers easy overclocking, while also featuring RGB lighting. It does not have dual BIOS, an easy CMOS reset option, integrated graphics, or an integrated CPU, and a single CPU socket is present. The board carries a three-year warranty.
The board features four DDR5 memory slots arranged across two channels, supporting a maximum capacity of 192GB. Standard RAM operation tops out at 5200 MHz, while overclocking can push speeds up to 7600 MHz. ECC memory is not supported.
The rear I/O provides a varied USB selection, including three USB 3.2 Gen 2 Type-A ports, two USB 3.2 Gen 1 Type-A ports, one USB 3.2 Gen 2 Type-C port, and two USB 2.0 ports. There are no USB 3.2 Gen 2x2, USB 4, Thunderbolt 3, or Thunderbolt 4 ports present, and no USB 3.2 Gen 1 Type-C port is included. Display output consists of one HDMI and one DisplayPort, while VGA and DVI outputs are absent. Networking is handled by a single RJ45 port, and there are no eSATA or PS/2 ports on this board.
Internal connectivity includes two M.2 sockets and four SATA 3 connectors for storage, with no SATA 2, mSATA, or U.2 sockets available. Expansion headers cover two USB 3.2 Gen 1 ports, two USB 3.0 ports, and four USB 2.0 ports, allowing additional front-panel or accessory connections. The board also provides five fan headers for cooling management and includes a TPM connector for security module support.
The board offers two PCIe 4.0 x16 slots for full-size expansion cards, alongside two PCIe x1 slots for smaller add-in cards. There are no PCIe 5.0, PCIe 3.0, PCIe 2.0, or PCIe x8 slots, and no legacy PCI slots are present.
Audio output supports 7.1-channel sound through five analog audio connectors on the rear panel, and an S/PDIF output is also included for digital audio passthrough to compatible receivers or DACs.
The board supports RAID 0, RAID 1, and RAID 10 configurations for drive arrays, offering options for performance striping, mirroring, and a combination of both. RAID 5 and RAID 0+1 are not supported.