The Asus Prime B650M-R uses an AM5 socket paired with a B650 chipset and comes in the compact Micro-ATX form factor, measuring 221 mm by 236 mm. It features a single CPU socket and does not include an integrated CPU or integrated graphics. The board supports easy overclocking and includes an accessible BIOS reset option, while RGB lighting adds a degree of visual customization. Wi-Fi and Bluetooth are not built in, and the board lacks a dual BIOS setup. HDMI 2.1 is available for display output, and the unit is backed by a 3-year warranty.
The board supports DDR5 memory across two slots in a dual-channel configuration, with a maximum capacity of 96GB. Standard operation reaches up to 5200 MHz, while overclocked profiles can push speeds as high as 7200 MHz. ECC memory is not supported.
Rear port connectivity includes four USB 2.0 ports and two USB 3.2 Gen 1 Type-A ports, while USB Type-C, USB 3.2 Gen 2, USB 4, Thunderbolt 3, and Thunderbolt 4 are all absent. Display output is handled by a single HDMI port, with no DisplayPort, DVI, or VGA connector available. Networking is covered by one RJ45 port, and there are no eSATA or PS/2 ports present.
Internal connectivity is reasonably well-equipped, with two M.2 sockets and four SATA 3 connectors available for storage, while SATA 2 and U.2 sockets are not present and mSATA is unsupported. Expansion headers include two USB 3.2 Gen 1 ports and two USB 3.0 ports for additional front-panel USB connectivity, along with four USB 2.0 ports through expansion. The board also provides three fan headers for cooling management and includes a TPM connector for security module support.
Expansion options are modest but focused, with a single PCIe 4.0 x16 slot for a primary add-in card such as a graphics card, alongside one PCIe x1 slot for smaller expansion cards. There are no PCIe 5.0, PCIe 3.0, PCIe 2.0, PCIe x4, PCIe x8, or legacy PCI slots on this board.
The board offers 7.1-channel audio support alongside three audio connectors for analog output and input. There is no S/PDIF Out port available for digital audio passthrough.
The board supports RAID 0, RAID 1, and RAID 10 configurations, covering striping, mirroring, and a combination of both. RAID 5 and RAID 0+1 are not supported.