The Sapphire B650M-E uses the AM5 socket with a compatible B650 chipset and comes in a Micro-ATX form factor measuring 244 x 235 mm, fitting neatly into compact cases. It supports overclocking and carries a three-year warranty, while omitting Wi-Fi, Bluetooth, RGB lighting, dual BIOS, easy CMOS reset, and integrated graphics. The board accommodates a single CPU and has no integrated processor of its own.
The board runs DDR5 memory across two slots in a dual-channel configuration, supporting a maximum capacity of 96 GB and overclocked speeds of up to 7600 MHz. ECC memory is not supported.
The rear panel provides two USB 3.2 Gen 1 Type-A ports and six USB 2.0 ports for peripheral connectivity, while USB Type-C, USB 3.2 Gen 2, USB 4, Thunderbolt, eSATA, and PS/2 ports are absent. Display output is handled by an HDMI port and one DisplayPort, with no DVI or VGA connectors present. A single RJ45 port covers wired network connectivity.
Internal connectivity includes two M.2 sockets and four SATA 3 connectors for storage, with no SATA 2, U.2, or mSATA options present. For USB expansion via headers, the board offers two USB 3.2 Gen 1 connectors, two additional USB 3.0 connectors, and four USB 2.0 connectors.
Expansion options are modest but focused, with one PCIe 4.0 x16 slot serving as the primary slot for a dedicated graphics card or similar full-bandwidth card, alongside one PCIe x4 slot for additional expansion. There are no PCIe 5.0, PCIe 3.0, PCIe 2.0, PCIe x1, PCIe x8, or legacy PCI slots on this board.
The board supports 5.1 surround audio with three analog audio connectors on the rear panel. There is no S/PDIF Out port for digital audio output.
The board does not support RAID 0+1 storage configuration.